Integrated Processing
Extraction, enrichment, and concentration are brought together within the cartridge-based workflow.
PRODUCTS · REVOLUTION SAMPLE PREP
Revolution Plus System and Kits
Flexible liquid biopsy sample preparation across a broad range of analytes, sample types, and input volumes.
Revolution Plus supports cell-free nucleic acid extraction and CTC enrichment using the appropriate kit and single-use nRicher Cartridge. Its semi-automated workflow combines instrument processing with operator-performed steps.
PART NUMBER
PN 2000-PLUS
SYSTEM
Revolution Plus
WORKFLOW
Semi-Automated
01
CELL-FREE ANALYTES
Up to 50 mL
02
CTC ENRICHMENT
Dedicated RUO Kits
Analytes
cfDNA · cfRNA · cfTNA · CTCs
Sample Types
Plasma · Urine · Blood · Other Fluids
Cell-Free Input
Up to 50 mL
Workflow Foundation
nRicher Cartridge
SEMI-AUTOMATED WORKFLOWS
Revolution Plus.
Revolution Plus.
Your choice of wash and elution workflow.
Use Revolution Plus with manual wash and elution, or transfer samples to Hamilton STAR for automated wash and elution in supported workflows. Both configurations are semi-automated.
The Hamilton configuration includes operator involvement during Plus processing and a manual transfer to Hamilton STAR.
Explore Hamilton WorkflowsRevolution PlusOperator
transfer
transfer
Hamilton STAR
THE RECOVERY FOUNDATION
Single-use nRicher Cartridge
BUILT AROUND RECOVERY
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The nRicher Cartridge is at the center of the Revolution workflow.
The patented Revolution technology combines extraction, enrichment, and concentration in a single-use cartridge architecture.
By reducing the need for yield-lowering sample transfers, re-elutions, and pooling multiple extractions from the same sample, Revolution Plus is designed to handle both small- and large-volume sample preparation workflows.
Fewer Transfers
Designed to limit workflow steps that can introduce unnecessary sample handling and recovery loss.
Broad Sample Range
Supports liquid biopsy workflows across plasma, urine, blood, and other bodily fluids.
Volume Flexibility
Supports cell-free analyte inputs up to 50 mL and larger-volume CTC and other application workflows.
TWO OPERATING MODES
Standardized kit workflows or user-programmable research flexibility.
Revolution Plus operates in two different modes using separate USB keys, allowing laboratories to move between approved kit protocols and research workflow development.
Approved Revolution Protocols
Kit Mode runs extraction according to the latest approved Revolution protocol for the selected compatible kit.
Standardized Workflow
User-Programmable Operation
Research Mode is available separately and provides user-programmable operation for research workflow development.
Available Separately · RUO
REVOLUTION PLUS INTERFACE
Kit Mode + Research Mode
SYSTEM RESOURCES
Manuals & firmware
Access current Revolution Plus operating documentation and Kit Mode firmware resources.
REVOLUTION KIT PORTFOLIO
Match the kit to your analyte and input volume.
Revolution kits pair analyte-specific reagents with nRicher Cartridges sized for the intended sample-volume range. Reagent-only kits are also available for utilization of excess cartridges where noted.
IVD · cfDNA
Revolution cfDNA Max 20 Kit
PN 408000
- Input Volume
- 1–20 mL
- Starting Samples
- Blood, Plasma, Urine, CSF
- nRicher Cartridges
- 24
- List Price
- $600 USD
IVD · cfDNA
Revolution cfDNA Max 50 Kit
PN 405000
- Input Volume
- >20–50 mL
- Starting Samples
- Blood, Plasma, Urine, CSF
- nRicher Cartridges
- 24
- List Price
- $1,995 USD
IVD · cfTNA / cfRNA
Revolution cfTNA Max 20 Kit
PN 408500
- Input Volume
- 1–20 mL
- Starting Samples
- Blood, Plasma, Urine
- nRicher Cartridges
- 24
- List Price
- $600 USD
COMING SOON · cfTNA / cfRNA
Revolution cfTNA Max 50 Kit
PN 406500
- Input Volume
- >20–50 mL
- Starting Samples
- Blood, Plasma, Urine
- nRicher Cartridges
- 24
- List Price
- $1,995 USD
RUO · CTC
Revolution CTC Enrichment Kit
PN 407000
- Input Volume
- 1–50 mL*
- Starting Sample
- Whole Blood
- nRicher Cartridges
- 12
- List Price
- $1,788 USD
Find the kit that fits your workflow.
Filter the Revolution portfolio by analyte, sample type, and input sample volume.
Open Kit Selector
KIT DETAILS
Revolution kit configurations
Open each kit family below for included components, extraction capacity, reagent-only options, and available resources.
cfDNA · 1–20 mL Revolution cfDNA Max 20 Kits
COMPLETE KIT
Revolution cfDNA Max 20 Kit
PN 408000 · $600 USD
For input sample volumes such as plasma and urine from 1 mL–20 mL. Includes nRicher Cartridges and kit reagents.
Kit includes 24 × 50 mL nRicher Cartridges and sufficient reagents for:
24 × 1–5 mL
12 × 6–10 mL
8 × 11–15 mL
6 × 16–20 mL
Eluted nucleic acid is suitable for NGS, PCR, and other downstream molecular biology assays.
REAGENT-ONLY OPTION
Revolution cfDNA Max 20 Reagent Kit
PN 401000 · $480 USD. Supplemental reagents for use with excess cfDNA Max 20 nRicher Cartridges. nRicher Cartridges are not included.
cfDNA · >20–50 mL Revolution cfDNA Max 50 Kits
COMPLETE KIT
Revolution cfDNA Max 50 Kit
PN 405000 · $1,995 USD
Designed for larger input sample volumes greater than 20 mL through 50 mL. Includes nRicher Cartridges and kit reagents.
Kit includes 24 × 100 mL nRicher Cartridges and sufficient reagents for:
24 × 21–30 mL
18 × 31–40 mL
12 × 41–50 mL
Eluted nucleic acid is suitable for NGS, PCR, and other downstream molecular biology assays.
REAGENT-ONLY OPTION
Revolution cfDNA Max 50 Reagent Kit
PN 404000 · $1,875 USD. Supplemental reagents for use with excess cfDNA Max 50 nRicher Cartridges. nRicher Cartridges are not included.
cfTNA / cfRNA · 1–20 mL Revolution cfTNA Max 20 Kits
COMPLETE KIT
Revolution cfTNA Max 20 Kit
PN 408500 · $600 USD
For input sample volumes such as plasma and urine from 1 mL–20 mL. The kit may be used to isolate circulating cell-free total nucleic acid (cfTNA) or cfRNA using an optional DNase digestion step.
Kit includes 24 nRicher Cartridges and sufficient reagents for:
24 × 1–5 mL
12 × 6–10 mL
8 × 11–15 mL
6 × 16–20 mL
Eluted nucleic acid is suitable for NGS, PCR, and other downstream molecular biology assays.
REAGENT-ONLY OPTION
Revolution cfTNA Max 20 Reagent Kit
PN 401500 · $480 USD. Supplemental reagents for use with excess cfTNA Max 20 nRicher Cartridges. nRicher Cartridges are not included.
cfTNA / cfRNA · >20–50 mL Revolution cfTNA Max 50 Kits
COMPLETE KIT · COMING SOON
Revolution cfTNA Max 50 Kit
PN 406500 · $1,995 USD
Designed for larger input sample volumes greater than 20 mL through 50 mL. Includes nRicher Cartridges and kit reagents.
Kit includes 24 × 100 mL nRicher Cartridges and sufficient reagents for:
24 × 21–30 mL
18 × 31–40 mL
12 × 41–50 mL
Eluted nucleic acid is suitable for NGS, PCR, and other downstream molecular biology assays.
REAGENT-ONLY OPTION · COMING SOON
Revolution cfTNA Max 50 Reagent Kit
PN 405500 · $1,875 USD. Supplemental reagents for use with excess cfTNA Max 50 nRicher Cartridges. nRicher Cartridges are not included.
CTCs · Whole Blood Revolution CTC Kits
ENRICHMENT KIT · RUO
Revolution CTC Enrichment Kit (Epithelial Origin)
PN 407000 · $1,788 USD
Uses proprietary magnetic beads and anti-EpCAM antibodies to isolate intact, viable epithelial-derived circulating tumor cells from whole blood.
Includes reagents and 12 × 50 mL nRicher Cartridges for CTC isolation
from RBC + Buffy Coat fractions of whole blood:
12 × 10 mL
6 × 20 mL
3 × 40 mL
Supports CTC enrichment from 1 mL up to 50 mL in a single extraction. Inquire about larger sample volumes up to 100 mL per extraction.
For Research Use Only. Not for use in diagnostic procedures.
REAGENT-ONLY OPTION · RUO
Revolution CTC Reagent Kit
PN 407600 · $1,728 USD. Supplemental CTC enrichment reagents for complete utilization of unused cartridges from the CTC Enrichment Kit. nRicher Cartridges are not included.
Reagent volumes support 12 CTC isolations of up to 10 mL of sample per nRicher Cartridge.
PRODUCT LABELING
Know the intended-use labeling for each workflow.
The Revolution Plus Sample Prep System is IVD-labeled. Revolution cfDNA and cfTNA kits, when used in Kit Mode on the Revolution Plus instrument, are IVD-labeled. The Revolution CTC Enrichment Kit (Epithelial Origin) and Revolution CTC Reagent Kit are labeled for Research Use Only and are not for use in diagnostic procedures.
BUILD YOUR REVOLUTION WORKFLOW