nRichDX_Revolution vs. QIAamp_QIAvac

There's Better Sample Prep for Liquid Biopsy

Sample prep that eliminates yield-lowering limitations found in other methods:

Sample transfers - moving samples from one vessel/container to another
Pre-concentration steps - reducing larger sample volumes to a volume compatible with the method being used, or to concentrate low-concentration/higher volume samples
Eluate re-elutions - reapplying the eluted sample back over the extraction matrix (like a silica membrane filter)
Eluate pooling for larger volumes - required for sample volumes exceeding the sample volume limit of the method used (e.g. often 5 mL - 10 mL depending on the specific method) necessitating extraction of the same sample in multiple separate extractions followed by pooling of the separate eluates (NOTE: eluate pooling may require an additional eluate concentration step depending on the input samplke volume threshold for the analysis method used)
"Clean-up" steps
Tedious, labor-intensive workflow requiring careful attention throughout the protocol - little walk away time with careful attention required throughout the protocol

Third-Party Data

This article compares the extraction of cell-free DNA (cfDNA) from plasma using two different kits: the paramagnetic bead-based nRichDX Revolution cfDNA Max 20 Kit and the column-based Qiagen QIAamp Circulating Nucleic Acid Kit. The authors reported that "paramagnetic bead-based cfDNA isolation [nRichDX] improved the recovery of cfDNA compared to the column-based [Qiagen] method... Across all metrics."

Clinical Chemistry (Journal) 2025 May 26; link to abstract: https://pubmed.ncbi.nlm.nih.gov/40415574/