Powering Liquid Biopsy

The Revolution Plus Platform

Smart, easy-to-use semi-automated extraction using nRichDX's Revolution kits for cfDNA, cfTNA/cfRNA, and CTCs.

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The Cartridge Makes the Difference

The unique nRicher Cartridge maximizes yield and purity by eliminating problems found in other methods. Only from nRichDX.

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Automated Solutions with Hamilton

As a Hamilton Trusted Partner, nRichDX's Revolution System and the Hamilton Microlab STAR liquid handler combine to create fully scalable automated liquid biopsy sample solutions.

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SABCS 2025 Poster - Detecting Breast Cancer Mutations in 50 mL Urine

Considering urine as a liquid biopsy biofluid for detection of cancer markers? Check out nRichDX's recent poster at the San Antonio Breast Cancer Symposium. Presented in collaboration with Anchor Molecular.

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See Our AMP 2025 Posters

nRichDX and collaborators presented four posters at the AMP 2025 Meeting & Expo in Boston. See them in detail on our Reference Materials webpage.

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What Users Say

"In our work with both cancer and neurological disease samples, the nRichDX platform has consistently given us high-quality, high-yield cfDNA. The workflow is straightforward and reliable, and it has genuinely improved the sensitivity and confidence of our liquid biopsy studies."

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On-Demand Webinar Video Now Available

Title: "Current Perspectives on RNA Liquid Biopsy: Impact of RNA Extraction on Assay Performance"

Date/Time: Held Thursday, October 16th at 9am PST/Noon EST/6pm CET

View Recorded Webinar

Investigating Cell-Free RNA?

nRichDX's Revolution cfTNA Max 20 and Max 50 Kits extract cell-free circulating Total Nucleic Acid, including cfRNA and ctRNA.

cfTNA Max 20 Kit cfTNA Max 50 Kit

Johns Hopkins University Lab Publication Features Revolution System

Full-Length Clonal Immunoglobulin Rearrangements in cfDNA: Improved Recovery and Sequencing by Xian, R. et. al

Reference Materials

Dartmouth Lab Validates Revolution System

Standardized Workflow and Analytical Validation of Cell-Free DNA Extraction for Liquid Biopsy Using a Magnetic Bead-Based Cartridge System by Sathyanarayana, S. et al.

Reference Materials

RNA Extraction Comparison

ASHG 2025 poster (Genewiz) concludes, "The nRichDX Revolution Plus System yielded more and higher-quality cfRNA, with measurable RIN values where other kits failed. This improved input enabled more sensitive detection of ALS-associated cryptic introns."

ASHG 2025 Poster

Not Sure Which Revolution Kit to Use?

Use the Revolution Kit Selector or view a summary table of Revolution Sample Prep Kits currently available on the Revolution Plus Sample Prep System.

Kit Selector Summary Table

The Overlooked Role of Sample Prep in Limiting Liquid Biopsy Sensitivity

Discover why spin columns fall short for rare liquid biopsy analyte extraction, particularly when scaling input volumes to more than 5 mL.

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Existing Methods: Inherent Limitations

Other liquid biopsy extraction methods use yield-lowering procedures

Sample Transfers - moving the sample from plasticware to plasticware during the extraction protocol, leaving small amounts of material behind with each sample transfer - including targeted rare analytes

Pre-extraction Sample Volume Concentration - Reducing the input sample volume to accommodate inherent volume limitations of the method

Re-elution of the extraction eluate - attempting to increase yield of analyte by passing the eluted sample over the extraction matrix repeatedly to boost yield of rare analytes

Pooling - extracting the same sample using multiple separate extractions and combining the eluates, which may require subsequent eluate volume concentration

Limited Input Sample Volumes - other methods usually have inherent maximum input sample volumes limited to less than or equal to 5 mL - 10 mL which may be insufficient for early detection of rare analytes*

*Other methods, including automated methods, are inherently sample-volume limited and typically must use one or more of the above yield-lowering schemes to extract from volumes greater than 5 mL - 10 mL. These methods were not specifically engineered for extraction of rare analytes such as ctDNA and ctRNA from larger volumes which may lead to lower yields. Lower yields of analytes in the assay lowers assay sensitivity and limit of detection (LoD) and may result in Quantity Not Sufficient (QNS) errors.

Easily Find the Revolution Sample Prep Kit Best Suited to Your Assay's Analyte, Sample Type, and Input Sample Volume. All Kits are for Use on the Revolution Plus Instrument.

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