Revolution Plus
Bring cfDNA, cfRNA, and cfTNA extraction and CTC enrichment into a semi-automated workflow with Revolution Plus. Choose application-specific kits for your sample type, target, and input volume.
Explore Revolution PlusREVOLUTION PRO · AUTOMATED LIQUID BIOPSY SAMPLE PREPARATION
Early detection
starts upstream.
Fully automated extraction with Revolution Pro/ES.
Built around the science. Ready for the laboratory.
When targets are scarce, what reaches the assay matters. Revolution Pro brings sample-input flexibility, molecular recovery, and automation together. Combine Pro with the Revolution Elution Station (ES) for fully automated processing as Revolution Pro/ES.
THE MOLECULAR INPUT YOUR ASSAY NEEDS.THE WORKFLOW YOUR LABORATORY NEEDS.
Let the science guide the input.
Evaluate sample volume against recovery and assay response with the Sensitivity Ladder™.
Choose the target. Match the workflow.
cfDNA, cfRNA, and cfTNA extraction with Pro. For CTC enrichment, explore Revolution Plus and its dedicated kit.
Bring automation into daily operation.
Choose fully automated Revolution Pro/ES or Revolution Pro + Hamilton STAR, which includes a manual rack transfer.
AMP 2026 · SEATTLE · BOOTH #915
The Revolution Pro launch.
The science behind it.
Explore fully automated Revolution Pro/ES processing and the evidence behind the workflow.
Join us at AMP to discuss your sample types, target analytes, and laboratory requirements. Connect input optimization through the Sensitivity Ladder™ with the Revolution platform and its automation options.
NOVEMBER 10–14, 2026 Seattle, Washington · Booth #915
Explore the launch.
Explore Revolution Pro/ES and Revolution Pro + Hamilton STAR to find the configuration that fits your laboratory.
Hear the extraction science.
Nafiseh Jafari, PhD: fully automated 1–50 mL plasma and urine cfDNA sample preparation.
Examine downstream performance.
nRichDX and GT Molecular: scalable plasma ctDNA extraction paired with digital PCR for low-frequency variants.
THE SENSITIVITY LADDER™
What determined your
assay’s sample volume?
Let assay performance guide the answer.
Was your input experimentally optimized, or inherited from an existing workflow? The Sensitivity Ladder™ provides a framework to measure the contribution of sample input.
INPUT · RECOVERY · ASSAY RESPONSE
LIQUID BIOPSY SAMPLE PREPARATION
Your sample prep should fit your science.
The molecular input your assay needs.
The workflow your laboratory needs.
From cell-free DNA and RNA extraction to circulating tumor cell enrichment, the Revolution platform brings sample preparation into focus. Match your target, sample type, and input volume to the right kit and workflow, with automation options for the way your laboratory works.
Explore the Revolution PlatformMolecular recoveryRecover molecular material for downstream analysis.
Input flexibilityEvaluate the input your assay needs.
Workflow fitChoose the automation your operation needs.
THE REVOLUTION PLATFORM
Built for your samples.
Ready for your next question.
Extract cfDNA, cfRNA, and total cell-free nucleic acid (cfTNA), or enrich circulating tumor cells (CTCs). The Revolution portfolio brings together instruments, application-specific kits, and automation options. Sample compatibility depends on the selected kit and protocol.
FLAGSHIP SYSTEM
Revolution Pro
Liquid biopsy sample preparation. Built for automation.
Prepare cfDNA, cfRNA, and cfTNA with system-specific kits and protocols. Choose Revolution Pro/ES for fully automated processing, or Revolution Pro + Hamilton STAR for automated wash and elution with a manual rack transfer.
Explore Revolution Pro
Hamilton STAR workflows
Extend Revolution Plus or Revolution Pro with automated wash and elution on Hamilton STAR. Choose the extraction system that fits your laboratory’s processing needs.
Explore Hamilton WorkflowsExtraction Service.
Bring your extraction project to our team. Discuss specimen type, input volume, target analyte, and downstream requirements to assess service fit.
Explore Extraction ServiceYOUR SAMPLE. YOUR ASSAY. YOUR WORKFLOW.
Find the workflow
for the work you do.
Translational & research teams
Explore supported sample types and analytes for your research question. Match extraction to the molecular material your downstream method needs.
Explore Scientific ReferencesAssay developers
For MCED, SCED, and MRD development, evaluate sample input alongside recovery and assay response. Use the Sensitivity Ladder™ to investigate where additional input adds meaningful value.
Watch the sample-input videoExplore the Sensitivity Ladder™Liquid biopsy service laboratories
Assess extraction against the sample volumes, sample mix, and processing schedule your service handles. Review Revolution Pro automation and system-specific kits.
Explore Revolution ProHospital & health system teams
Discuss specimen availability, downstream methods, and sample-preparation requirements with our team to identify a supported workflow for your program.
Discuss Your WorkflowReference laboratories
Evaluate automation, run configuration, hands-on steps, and daily processing requirements together. Compare system workflows and kit requirements for your operation.
Explore the Revolution PlatformPharma & biotech teams
Align extraction with the specimens and molecular targets in your research program. Explore supported workflows or discuss extraction-service support.
Explore Extraction ServiceExplore applications
THE SENSITIVITY LADDER™
What input does your
assay actually need?
Developing an assay? Measure the contribution of sample input.
The Sensitivity Ladder™ is our framework for evaluating how changes in input affect recovery and downstream assay response. Identify where meaningful performance gains plateau, then evaluate the lowest input in that region against specificity, background, reproducibility, sample quality, and workflow requirements.
Performance optimization,
not volume maximization.
WATCH THE STORY
You can’t detect
what you don’t recover.
See why sample preparation belongs at the start of the assay-performance conversation.
THE SENSITIVITY LADDER™START UPSTREAM
EXPLORE THE EVIDENCE
Make your next decision
with the evidence in view.
Compare the questions studied, methods used, and results measured. Use the reference collection to assess relevance to your own samples and downstream workflow.
WHITE PAPERS
Explore the methods.
Review sample preparation approaches and the scientific questions behind them.
Explore White PapersPUBLICATIONS
Read the research.
Explore publications using or evaluating nRichDX workflows in their application context.
View PublicationsPOSTERS & TECHNICAL DATA
Examine the data.
Find application data and scientific posters across nRichDX workflows.
Explore ResourcesSTART WITH nRICHDX
Your science. Your operation.
Let’s find your workflow.
Tell us what you process, what your assay needs, and how your laboratory runs.
We’ll help you identify the nRichDX system, kit, or service to evaluate.