*Some applications will accommodate up to 100 mL of sample as they do not require the same volumes of buffers and reagents in the nRicher Cartridge. Other applications like cfDNA extraction from plasma or urine have a minimum input sample volume range of 1 mL - 50 mL. nRichDX has the widest sample range for a single automated extraction of any commercially available system. Contact nRichDX for more details on your specific application.
The integrated nRicher Cartridge -
maximizes yield of cfDNA, cfRNA, and CTCs primarily in two ways:
- Integration of the Sample Tube with a detachable Capture Tube and Mag Capsule, enables extraction and enrichment of rare analytes without the yield-lowering sample transfers between multiple plasticware containers found in other methods. This increases yield at any sample volume.
- An unequaled sample range from as little as 1 mL to 100 mL of samples depending on the application. The ability of the nRicher Cartridge to process larger volumes in a single extraction without resorting to yield-lowering schemes like eluate pooling from multiple separate extractions found in other methods increases yield for higher sample volumes
The Revolution Plus
Exclusively uses nRichDX nRicher Cartridges in Revolution Kits to process from 1-12 samples in a single run using a semi-manual workflow.
Features and Benefits of The Revolution Sample Prep System
Accuracy exceeding the competition
Recover more detectable mutations from liquid biopsies. The Revolution System was specifically designed to address the challenges of liquid biopsy. Competitor kits can't handle the same sample volumes and lack the recovery efficiencies built into The Revolution System for sample preparation.
Higher yields... even at low volumes
Using 5 mL of plasma, nRichDX had a significantly higher cfDNA yield than Competitor A and exponentially more yield at 15 mL
Revolution System cfDNA yield is proportionate across all sample input volumes
Recovery rates increase linearly relative to input size. Samples 1-4 all demonstrate linear recovery rates across the 5 mL-20 mL volume range, despite individual variability in cfDNA abundance (obtained using the Revolution System and the Revolution cfDNA Max 20 Kit).
Revolution System proportionately extracts the actionable cfDNA across all sample volumes
Broad compatibility across applications
Blood, plasma, urine, CSF and other biological fluids are sample matrices supported by the Revolution System. Other biological fluids such as sputum, surgical lavage, and others are in validation or are planned.
Revolutionary results for demanding diagnostic applications
Coming soon
Under development
Under development
References
- Up to 10X more target material than competing systems, based on numerous third-party evaluations. Contact nRichDX for more information.
- Sample volumes from 1 mL to 20 mL of plasma or urine, or up to 40 mL of whole blood
- 70%— 90%+ recovery rate for all sample volumes
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